Focusrite Scarlett 16i16 4th GenvsFocusrite Scarlett 2i2 4th Gen

Focusrite Scarlett 16i16 4th Gen and Focusrite Scarlett 2i2 4th Gen: 2 Focusrite audio interfaces compared side by side. They differ on 9 of 15 compared specifications.

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2 items	Focusrite Scarlett 16i16 4th Gen CurrentView details →	Focusrite Scarlett 2i2 4th Gen CurrentView details →
General
Manufacturer	Focusrite	Focusrite
Status	Current	Current
Released	2024	2023
Inputs & outputs
Mic preamps	2	2
Analogue inputs	6	2
Analogue outputs	4	2
Channels (in / out)	16 in / 16 out	2 in / 2 out
Headphone outputs	2 (independent)	1
Digital I/O	ADAT in/out, S/PDIF in/out	—
Connection & power
MIDI	5-pin DIN	None
Connection	USB-C (USB 2.0)	USB-C (USB 2.0)
Resolution	24-bit / 192 kHz	24-bit / 192 kHz
Bus-powered	Yes	Yes
Features
Loopback	Yes	Yes
Features	Air mode, Auto Gain, Clip Safe, Alt speaker switching	Air mode, Auto Gain, Clip Safe
Bundled software	Ableton Live Lite, Pro Tools Intro+, Cubase LE and the Hitmaker Expansion (Melodyne Essential, Addictive Keys, Addictive Drums 2, Softube amps and more)	Ableton Live Lite, Pro Tools Intro+, Cubase LE and the Hitmaker Expansion (Melodyne Essential, Addictive Keys, Addictive Drums 2, Softube amps and more)
Size & weight
Dimensions (W × D × H)	220 × 155.2 × 60.5 mm	180 × 117 × 47.5 mm
Weight	1.25 kg	0.6 kg

Key differences

Analogue inputs: Scarlett 16i16 4th Gen – 6 Scarlett 2i2 4th Gen – 2
MIDI: Scarlett 16i16 4th Gen – 5-pin DIN Scarlett 2i2 4th Gen – None
Released: Scarlett 16i16 4th Gen – 2024 Scarlett 2i2 4th Gen – 2023
Analogue outputs: Scarlett 16i16 4th Gen – 4 Scarlett 2i2 4th Gen – 2
Channels (in / out): Scarlett 16i16 4th Gen – 16 in / 16 out Scarlett 2i2 4th Gen – 2 in / 2 out
Headphone outputs: Scarlett 16i16 4th Gen – 2 (independent) Scarlett 2i2 4th Gen – 1

Both are the same on mic preamps (2) and bus-powered (Yes).

Summary

Key differences